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Opana ER, with its active ingredient being oxymorphone, is an extended-release opioid analgesic primarily used for the management of severe pain that requires continuous, around-the-clock opioid treatment and for which alternative treatment options are inadequate. The “ER” in its name stands for “extended-release,” indicating that the medication is formulated to release the active ingredient over time, providing prolonged pain relief.

Oxymorphone, the primary component of Opana ER, works by binding to opioid receptors in the brain and spinal cord, thereby reducing the perception of pain.

Because of its potency and the inherent risks associated with opioids, Opana ER should be prescribed only to patients who have already been receiving opioid medications, as they are more tolerant to its effects. Opioids can be habit-forming, and misuse can lead to addiction, overdose, or even death. Common side effects include drowsiness, dizziness, constipation, and nausea.

It’s also worth noting that Opana ER faced scrutiny due to concerns about misuse, which prompted its manufacturer to reformulate the drug to make it more resistant to tampering. Nonetheless, due to ongoing concerns about its potential for abuse and related health risks, the U.S. Food and Drug Administration (FDA) requested the removal of Opana ER from the market in 2017, and its manufacturer complied.

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