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Salvinorin A is a potent hallucinogenic compound found in the plant Salvia divinorum. It is the most potent naturally occurring hallucinogen known to date, with effects distinct from those of other well-known psychedelic substances like LSD, psilocybin, or mescaline.

Salvinorin A - Wikipedia

Structure and Chemistry

Salvia belongs to the diterpenoid class of organic compounds. Its molecular formula is C22H30O7, and it has a molecular weight of 402.5 g/mol. The compound’s structure consists of a highly oxygenated tetrahydrofuran (THF) ring fused to a 16-membered lactone ring. This unique structure is responsible for its potent and unique pharmacological properties.

Pharmacology and Mechanism of Action

Salvinorin A interacts with the kappa opioid receptor (KOR), making it the first known naturally occurring substance to do so. Unlike other hallucinogens that primarily target serotonin receptors, salvia’s mechanism of action is primarily through the kappa opioid receptor. This interaction leads to the characteristic dissociative and hallucinogenic effects experienced by users.

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Effects and Dosage

The effects of salvinorin A are typically short-lasting, with a duration of around 30 minutes to 2 hours. The onset of effects can be rapid, occurring within minutes of ingestion or inhalation. Common reported effects include:

  1. Altered perception of reality, including visual and auditory hallucinations
  2. Dissociation from one’s physical and emotional self
  3. Euphoria or dysphoria (depending on the individual and dosage)
  4. Temporary loss of motor control and balance
  5. Anesthesia or numbness in certain body parts

Dosages can vary greatly depending on the method of administration. Smoking or vaporizing salvia extract is considered the most effective method, with doses as low as 200 micrograms (µg) being sufficient to produce effects. In contrast, oral ingestion requires much higher doses, typically ranging from 2 to 5 mg.

Safety and Risks

Due to its potency and unique mechanism of action, salvia can pose significant risks to users. Some potential risks include:

  1. Unpredictable and intense hallucinogenic effects
  2. The possibility of experiencing a “bad trip” or psychological distress
  3. Physical harm due to loss of motor control and balance
  4. Potential for addiction or dependence, although the long-term effects are not yet fully understood

It is crucial to note that the safety and efficacy of salvia have not been evaluated through rigorous scientific research, and its use is not approved by regulatory agencies like the FDA.

Legal Status

In many countries, including the United States, salvia is considered a legal herb, and its extract containing salvinorin A is also legal for personal use. However, some jurisdictions have banned or restricted the sale and possession of salvia products due to concerns about their potential risks and abuse. It is essential to check the local laws and regulations before considering the use or possession of salvinorin A or salvia products.

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